Recently, small and medium-sized companies have expanded their activities internationally. However, the process of internationalization is not easy, and given the increasing competition in international markets, and the lack of resources, knowledge, and experience of these companies in international markets, success in these markets is a major challenge for these companies. In this regard, the present study aimed to investigate the effect of a global mindset on networking and acquiring international knowledge with the mediating role of international entrepreneurship tendency in small and medium-sized companies. This study is a descriptive survey study in terms of its applied purpose and data collection method. The statistical population of the study included all export food industry companies in industrial estates in London. The required sample size was determined using the Cochran formula, 190 companies, and the samples were selected by simple random method. The data collection tool was a standard questionnaire, the validity of which was confirmed by face validity, convergent validity, and divergent validity. The results of the path analysis indicate that global mindset has a direct and significant effect on international knowledge acquisition and networking and international entrepreneurial orientation. The effect of international entrepreneurial orientation on international knowledge acquisition and networking was also confirmed. Finally, it was found that global mindset has an indirect and significant effect on international knowledge acquisition and networking through international entrepreneurial orientation. This research provides policymakers with solutions to develop the international activities of small and medium-sized enterprises, as the main arms of the UK in the national and industrial innovation system.